Quantitative trait loci analysis in animals

by Weller, J. I.

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Full title :Quantitative trait loci analysis in animals.

Summary

Historical overview. Principles of parameter estimation. Random and fixed effects, the mixed model. Experimental designs to detect QTL, generation of linkage disequilibrium. QTL parameter estimation for crosses between inbred lines. Advanced statistical methods for QTL detection and prameter estimation.Analysis of QTL as random effects. Statistical power do detec QTL, and parameter confidence intervals. Optimization of experimental designs. Fine mapping of QTL. Complete genome QTL scans - the problem of multiple comparisons. Multiple trait QTL analysis. Principles of selection index and traditional breeding programmes. Marker-assited selection - theory. Marker-assited selection - results of simulation studies. Marker-assisted introgression.