Ribozymes: principles, methods, applications

by Masquida, Benoît Müller, Sabine Winkler, Wade C.

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Title Statements

Full title :Ribozymes. : principles, methods, applications / edited by Sabine Müller, Benoît Masquida, Wade Winkler.

Edition Statements

Publication Date:©2021

Publication Statements

Publisher(s):Wiley-VCH
Place of Publication:Weinheim, Germany
Language:eng
Publication Date:©2021

Notes

21 In Vitro Selected (Deoxy)ribozymes that Catalyze Carbon-Carbon Bond Formation.

The Physical Object

Description:1 online resource (1076 pages)

Edition Identifiers

ISBN:3527814558, 9783527814558, 3527814523, 9783527814527, 3527814531, 9783527814534
oclc:on1317422527
LC Classification:QP623.5.C36
Dewey Decimal:572.88

Intro -- Table of Contents -- Title Page -- Title Page -- Copyright -- Preface -- Foreword -- References -- Volume 1 -- Part I: Nucleic Acid Catalysis: Principles, Strategies and Biological Function -- 1 The Chemical Principles of RNA Catalysis -- 1.1 RNA Catalysis -- 1.2 Rates of Chemical Reactions and Transition State Theory -- 1.3 Phosphoryl Transfer Reactions in the Ribozymes -- 1.4 Catalysis of Phosphoryl Transfer -- 1.5 General Acid-Base Catalysis in Nucleolytic Ribozymes -- 1.6 pKa Shifting of General Acids and Bases in Nucleolytic Ribozymes -- 1.7 Catalytic Roles of Metal Ions in Ribozymes -- 1.8 The Choice Between General Acid-Base Catalysis and the Use of Metal Ions -- 1.9 The Limitations to RNA Catalysis -- Acknowledgment -- References -- 2 Biological Roles of Self-Cleaving Ribozymes -- 2.1 Introduction -- 2.2 Use of Self-cleaving Ribozymes for Replication -- 2.3 Self-cleaving Ribozymes as Part of Transposable Elements -- 2.4 Hammerhead Ribozymes with Suggested Roles in mRNA Biogenesis -- 2.5 The glmS Ribozyme Regulates Glucosamine-6-phosphate Levels in Bacteria -- 2.6 The Biological Roles of Many Ribozymes Are Unknown -- 2.7 Conclusion -- Acknowledgments -- References …