RNA editing: methods and protocols

by Pesole, Graziano Picardi, Ernesto

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Title Statements

Full title :RNA editing : methods and protocols / edited by Ernesto Picardo and Graziano Pesole.

Summary

Edition Statements

Publication Date:2021

Publication Statements

Publisher(s):Humana Press
Place of Publication:New York, NY
Language:eng
Publication Date:2021

Notes

This volume provides an overview about main RNA editing mechanisms, focusing on their functions in physiological as well as pathological conditions. Chapters guide readers through state- of-the art methodologies to investigate RNA editing through wet and dry approaches.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, RNA Editing: Methods and Protocols aims to ensure successful results in the further study of this vital field.

1. Substitutional RNA Editing in Plant Organelles; Mizuho Ichinos and Mamoru Sugita; ; 2. Computational Detection of Plant RNA Editing Events; Alejandro A. Edera and M. Virginia Sanchez-Puerta; ; 3. Discovering RNA Editing Events in Fungi; Huiquan Liu and Jin-Rong Xu; ; 4. C-to-U RNA Editing: From Computational Detection to Experimental Validation; Taga Lerner, Mitchell Kluesner, Rafail Nikolaos Tasakis, Branden S. Moriarity, F.N. Papavasiliou, and Riccardo Pecori; ; 5. Live Cell Quantification of APOBEC1-mediated RNA Editing: A Comparison of RNA Editing Assays; Martina Chieca, Serena Torrini, and Silvestro G. Conticello; ; 6. Adenosine to Inosine RNA Editing Enzyme ADAR and microRNAs; Kang Yuting, Dan Ding, and Hisashi Iizasa; ; 7. Quantitative Analysis of Adenosine-to-Inosine RNA Editing; Turnee N. Malik, Jean-Philippe Cartailler, and Ronald B. Emeson; ; 8. .

- Discovering A-to-I RNA Editing Through Chemical Methods; Masayuki Sakurai, Shunpei Okada, Hiroki Ueda, and Yang Yuxi; ; 9. ALU A-to-I RNA Editing - Millions of Sites and Many Open Questions; Amos Schaffer and Erez Y. Levano; ; 10. RNA Editing in Human and Mouse Tissues; Harini Srinivasan, Eng Piew Louis Kok, and Meng How Tan; ; 11. Bioinformatics Resources for RNA Editing; Maria Angela Diroma, Loredana Ciaccia, Graziano Pesole, and Ernesto Picardi; 12. High-throughput Sequencing to Detect DNA-RNA Changes ; Claudio Lo Giudice, Graziano Pesole, and Ernesto Picardi; ; 13. Detection of A-to-I Hyper-Edited RNA Sequences; Roni Cohen-Fultheim and Erez Y. Levanon ; ; ; 14. Proteome Diversification by RNA Editing; Eli Eisenberg; ; 15. .

- MicroRNA Editing Detection and Function: A Combined in silico and Experimental Approach for the Identification and Validation of Putative Oncogenic Targets; Valentina Tassinari, Valeriana Cesarini, Domenico Alessandro Silvestris, Andrea Scafidi, Lorenzo Cucina, and Angela Gallo; ; 16. RNA Editing in Interferonopathies; Loredana Frassinelli, Silvia Galardi, Silvia Anna Ciafrè, and Alessandro Michienzi; ; 17. The Role of RNA Editing in the Immune Response; Sadeem Ahmad, Xin Mu, and Sun Hur; ; 18. RNA Editing in Neurological and Neurodegenerative Disorders; Pedro Henrique Costa Cruz and Yukio Kawahara; ; 19. New Frontiers for Site-directed RNA Editing - Harnessing Endogenous ADARs; Tobias Merkle and Thorsten Stafforst;.