Somatostatin

by Srikant, Coimbatore B.

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Title Statements

Full title :Somatostatin / edited by Coimbatore B. Srikant.

Summary

This volume presents the state-of-the-art description of the current understanding of the biology of somatostatin including its gene regulation, prosomatostatin processing, cellular effects, somatostatin receptor subtypes, mechanism of action, signal transduction, regulation of cell growth and apoptosis, design and use of receptor subtype-selective somatostatin analogs, derivatives of somatostatin analogs tagged with radionuclides/chemotoxins, and their clinical relevance in the diagnosis and treatment of cancer. Each chapter is written by expert(s) active in somatostatin research (experimental and/or clinical). It will serve as the only single one-stop source of the most up to date information on the basic and clinical aspects of the biology of somatostatin and its receptors.

Edition Statements

Publication Date:©2004.

Publication Statements

Publisher(s):Kluwer Academic Publishers
Place of Publication:Boston
Language:eng
Publication Date:©2004.

The Physical Object

Description:1 online resource (xvi, 311 pages) : : illustrations (some color)

Edition Identifiers

ISBN:1402080336, 9781402080333, 1402077998, 9781402077999
oclc:ocm57047467
LC Classification:QP572.S59
Dewey Decimal:612.4/05

Preface / Coimbatore B. Srikant -- Note on Nomenclature / Coimbatore B. Srikant -- Part I. Somatostation : General Biology -- 1. Somatostatin Gene Structure and Regulation / Mario Vallejo -- 2. Processing and Intracellular Targeting of Somatostatin / Rania Mouchantaf, Yogesh C. Patel, and Ujendra Kumar -- 3. Cortistatin : A Novel Member of the Somatostatin Gene Family / Veronique Fabre [and others] -- 4. Molecular Evolution of Somatostatin Genes / Herve Tostivint [and others] -- 5. Altered Patterns of Growth Hormone Secretion in Somatostatin Knockout Mice / Malcolm J. Low, Marcelo Rubinstein, and Veronica Otero-Corchon -- Part 2. Expression and Function of Somatostation Receptors -- 6. Somatostatin Receptor Gene Family : Subtype Selectivity for Ligand Binding / Jason P. Hannon [and others] -- 7. Expression of Somatostatin Receptors in Human Tissues in Health and Disease / Jean Claude Reubi, Beatrice Waser and Jean-Claude Schaer -- 8. Coexpression of Multiple Somatostatin Receptors in Individual Cells / Robert Gardette [and others] -- 9. Somatostatin Receptor Subtype Selectivity for Cytotoxic and Cytostatic Signaling / Coimbatore B. Srikant -- 10. Somatostatin Receptor Signaling vi…

Subjects

Évolution moléculaire Evolution, Molecular Gene Targeting Gènes -- Ciblage MEDICAL -- Physiology Molecular evolution Receptors, Somatostatin SCIENCE -- Life Sciences Somatostatin Somatostatin -- analogs & derivatives Somatostatin -- genetics Somatostatin -- therapeutic use Somatostatine