Translational vascular medicine: pathogenesis, diagnosis, and treatment

Modern medicine is increasingly focused on integrating the results of basic scientific research and clinical research, "translational medicine" to provide improved patient care. This collaborative approach which is a "two way street" has proven very useful in various fields in cardiovascular medicine. Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment provides extensive information on new and exciting advances in such topics as surgery and non-pharmacological treatments for atherosclerotic disease of the aorta, pulmonary arterial hypertension, cytoprotective mechanisms in the vasculature, and the "Broken Heart Syndrome". The Editors and their expert panel of contributors have explored the bi-directional and integrated approaches of translational cardiovascular medicine, linking basic science to patient care. This book is a highly useful method to understand these complex topics and provides considerable insight into important areas of translational cardiovascular medicine and key bibliographies for the reader

Section 1 -- Hot Topics in Vascular Biology -- 1. Pericytes: Adaptable vascular progenitors -- 2. Benefits and risks of manipulating the HIF hydroxylase pathway in ischaemic heart disease -- 3. Cytoprotective mechanisms in the vasculature -- 4. Notch signalling in vascular development -- Section 2 -- Novel Molecular Mediators Regulating Cardiovascular System -- 5. The therpeutic potential of dimethylarginine dimethylaminohydrolase mediated regulation of nitric oxide synthesis. -- 6. Potassium channels regulating the electrical activity of the heart -- 7. Free radicals oxidant stress and cardiovascular disease -- Section 3 -- Clinical Aspects of Cardiovascular Disease -- 8. The Broken Heart Syndrome -- 9. Lymphatic endothelium in health and disease -- 10. Importance of sub-type selectivity for endothelin receptor antagonists in the human vasculature -- 11. Non-pharmacological treatment of PAD -- 12. Surgical Approaches to Abdominal Aortic Aneurysm Repair -- Section 4 -- Clinical and translational Aspects of Pulmonary Vascular Disease -- 13. Understanding the pathobiology of pulmonary vascular disease -- 14. Inflammation in pulmonary arterial hypertension.