Vascular responses to pathogens

Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease.

Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Overview -- Chapter 1 -- Sepsis -- Introduction -- The microcirculation in sepsis -- The endothelium -- Nitric oxide and sepsis -- Arterioles -- Capillaries -- Venules -- Permeability -- Blood cells -- The Inflammatory Response in Sepsis -- Platelets in sepsis -- Thrombosis and coagulation in sepsis -- Models -- Genetics and sepsis -- Treatments for sepsis -- Conclusions -- Acknowledgment -- References -- Chapter 2 -- Neutrophil-Mediated Vascular Host Defense

IntroductionBloodstream infections -- Conventional vascular host defense -- Neutrophil extracellular trap mediated vascular immunity -- Immunothrombosis -- NET-mediated tissue damage -- Conclusions -- References -- Chapter 3 -- Platelets as Mediators of the Vascular Response to Infection -- Introduction -- Platelet and hemostasis -- Platelets and the response to infection -- Platelet-bacteria interactions -- Direct binding -- Indirect binding -- Shear stress -- Secreted products -- Platelet activation -- Platelets and sepsis -- Conclusions

GBS Surface Adhesins and InvasinsGBS Pili and Other ECM-Binding Proteins -- Signal-transduction mechanisms -- …