The inflammasomes
by Couillin, Isabelle, Pétrilli, Virginie, Martinon, Fabio
fromPIR (Collection : En ligne)
The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1b and IL-18. This finding was substantiated by the identification of several mutatio…