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More than 23 million Americans currently have diabetes and approximately 54 million have pre-diabetes. People with diabetes often also require medications for several co-morbid conditions (including hypertension, dyslipidemia, depression, heart disease, pain syndromes). Yet, a v…
Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in exper…