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1. Introduction. 1.1. Discovery of AID. 1.2. Current model of AID function. 1.3. Open questions. 1.4. A unifying model for AID function. 1.5. Acknowledgements. 1.6. References -- 2. Switch regions, chromatin accessibility and AID targeting. 2.1. Introduction. 2.2. Transcriptiona…
This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch re…