Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomera…
Telomeres and telomerase are the two pivotal players that determine the course of cellular sensecence and immortalization. A universal problem for all eukaryotic cells with linear chromosomes is telomere shortening due to "end-replication problems;" its compensation by telomeras…
Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomera…