In this project, two aspects of the action of hydrogen sulfide and reactive sulfur species have been studied: cytotoxic and cytoprotective effects. Freshly isolated hepatocytes have been used in order to examine the prevalence and mechanisms of the different sulfide dependent pr…
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Hydrogen sulfide was found to be more toxic to hippocampal slice cultures than isolated hepatocytes. Chloride ion channel blockers decreased H 2S cytotoxicity suggesting that H2S enters the cells via these channels. Intracellular H2S was formed from cysteine, metabolism as the c…