S. Arab

In this thesis, the use of verotoxin1 as a new approach to the management of certain human neoplasms and its mechanism of action in causing cell death is discussed. VT1 cytotoxicity was demonstrated on human cervical cancer, astrocytoma and ovarian tumor and multidrug resistant …

Verotoxins (VT), comprise a family of toxins that are produced by certain strains of Escherichia coli. VTs show similar biological activities but various antigenicities. The specific cell surface receptor for VT1, VT2, and VT2c is a glycolipid, globotriosylceramide, Gb3. A novel…