All organisms must prioritize investment in either reproductive or self-maintenance activities. Despite this established paradigm, our understanding of how organisms choose to prioritize certain behaviors and physiologies over others remains limited. It is likely that an organis…
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The overall aim of the work presented in this thesis was to further characterise aspects of metabolic and immune system cross-talk in human subcutaneous adipose tissue, with a particular emphasis on the potential role of T-lymphocytes in adipose tissue dysfunction and insulin re…
Obesity is the most well-established risk factor for type 2 diabetes mellitus (T2DM), although the underlying pathophysiological mechanisms have yet to be fully described. A growing body of evidence suggests that obesity directly induces chronic subclinical inflammation, which i…