Reef-building corals globally face an increasing assortment of existential threats, ranging from disease outbreaks to intensifying climate change, resulting in wide-scale population declines. Until recently, our understanding of coral evolutionary genetics, as well as any potent…
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The study of molecular containers has accelerated dramatically since the 1960's. The introduction of cucurbit[n]urils has contributed tremendously and continues to contribute to the expansion of the field. Chapter 1 introduces cucurbit[n]urils and their molecular recognition pro…
In this thesis, two potential applications of transdermal iontophoresis in the field of sports medicine were studied: (1) the local delivery of dexamethasone phosphate (Dex-Phos), a corticosteroid used to treat musculoskeletal inflammation, and (2) the extraction of systemic ami…
Environmental enteropathy (EE) is thought to underlie stunting, a widely prevalent phenomenon in the developing world with lifelong detrimental consequences. EE is characterised by increased intestinal permeability and reduced absorptive capacity in a chronically inflamed gut, a…
Ligand-observed NMR spectroscopy is frequently employed in early-stage drug discovery, often as an initial screen to narrow the field of potential drug-like molecules. However, its use is limited to this early stage. More information regarding binding mode can be extracted from …
Computational proteogenomic integrates proteomics with genomics and transcriptomics data and has emerged over the past decade as a useful discipline for functional annotation of genomes. It has been driven by high-throughput technologies from mass spectrometry and next generatio…
The solute carrier (SLC) SLC16 gene family comprises 14 members and encodes for monocarboxylate transporters (MCTs), which mediate the absorption and distribution of monocarboxylic compounds across plasma membranes. As the knowledge about their physiological function, activity, …
Several synthetic techniques have been established for the synthesis and ligation of peptide fragments, and the recent discovery of the decarboxylative ligation of α-ketoacids and N-alkylhydroxylamines has the means to advance chemical synthesis of proteins and peptides due to t…
A novel method has been developed for the measurement of the activity coefficients of an amino acid and the mean ionic activity coefficients of an electrolyte in water-electrolyte-amino acid systems. The method uses an electrochemical cell with two ion selective electrodes and a…
Splicing factors bind, in most cases, to a degenerate motif in the pre-mRNA of the target gene and either recruit or repel the spliceosome to/from nearby splice sites. Many splicing factors possess RNA-independent functions, such as protein-protein interactions in cellular compl…
Astrocytes maintain ion and neurotransmitter homeostasis within the central nervous system. They do so by expressing channels, receptors and transporters such as excitatory amino acid transporters (EAATs) along their highly ramified arbours. EAATs are well known to be glutamate …
Background. Millions worldwide are being exposed to arsenic through drinking water, which is associated with increased risks of skin cancer. Results from experimental research have found that dietary protein and specific amino acids may assist with arsenic methylation and conseq…