Aneuploidy can have contradictory effects on organisms and cells, from developmental disorders and cancer in humans to drug resistance and adaptive advantage in yeast. Despite a long history of involvement in human health and innumerable cases in other model organisms, how aneup…
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Mutations in the STAG2 gene are present in approximately 20% of tumors from different tissues of origin. STAG2 encodes a subunit of the cohesin complex, and tumors with loss of function mutations are usually aneuploid and display elevated frequencies of lagging chromosomes durin…