Endothelial cell (EC) activation is a change of the endothelium from a quiescent state to one that is involved in immune reactions. Activation of ECs is associated with the inception of atherosclerosis. Atherosclerosis is a chronic inflammatory disease that involves adaptive and…
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Air pollution has been associated with cardiovascular diseases (CVD) by many epidemiology studies. However, the components of air pollution that are responsible for the CVD are unknown and the mechanisms underlying the associations need to be elucidated. The objectives of this s…
Peanuts contain several cardiovascular beneficial nutrients and have been reported to reduce risk of cardiovascular diseases (CVD). Hypertension, hypercholesteremia, and atherosclerosis are leading causes of CVD. The first stage of atherosclerotic disease is accumulation of chol…
Many epidemiological studies have shown that elevated levels of fibrinogen are associated with cardiovascular disease. To investigate the influence of elevated fibrinogen in atherosclerosis, me generated a transgenic mouse model of hyperfibrinogenemia. A P1 clone containing the …
Cysteine proteases cathepsins are lysosomal enzymes that regulate numerous lysosomal functions but were also appreciated for their extra-lysosomal activities and their contribution to various pathologic conditions. Given the diversity in cathepsin function, we set out to explore…
Atherosclerotic plaque rupture at the carotid bifurcation is a major cause of stroke. While plaques vulnerable to rupture progress under significant influence from the local biochemical environment, and often experience a chronic or acute inflammatory process, mechanical forces …
Serum paraoxonases (PONs) comprise a family of mammalian hydrolases that exhibit a wide range of promiscuous activities, including organophosphate (OP) hydrolysis. Human PON1 is associated with high-density lipoprotein (HDL) and plays a key role in the prevention of atherosclero…
Representational Difference Analysis (RDA) was used to identify genes that were differentially expressed between White Carneau (WC) and Show Racer (SR) pigeon aortic smooth muscle cells. The gene(s) responsible for atherosclerotic resistance in cultured SR smooth muscle cells (S…
Handbook of the Vulnerable Plaque
by ProQuest (Firm), Waksman, Ron, Serruys, P. W., Schaar, Johannes
0
Type: Book
Since publication of the First Edition, advances in the diagnosis and prevention and treatment strategies of the vulnerable plaque have necessitated this greatly expanded second edition. With several new chapters covering mainly diagnostic and treatment options, The Handbook of …