Central nervous system

The permeation of drugs across the blood-brain barrier (BBB) is a prerequisite for central nervous system (CNS) drug penetration. The BBB, possessing efflux transporters and tight junctions, limits drug penetration to the brain. Consequently, the discovery of novel drugs to trea…

We are interested in studying the roles of serine/threonine kinases from Drosophila melanogaster. Drosophila has been studied as a genetic system for over a century. Thus numerous approaches are available to generate, maintain, and manipulate genetic mutants (Ashburner, 1989; Fl…

This thesis addressed several aspects of protective autoimmunity in the CNS under pathological and physiological conditions. My research findings are summarized below. Using a mouse model of retinal ganglion cell (RGC) loss induced by local injection of aggregated β-amyloid pept…