Mutations in the STAG2 gene are present in approximately 20% of tumors from different tissues of origin. STAG2 encodes a subunit of the cohesin complex, and tumors with loss of function mutations are usually aneuploid and display elevated frequencies of lagging chromosomes durin…
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The basic goals of my work are to understand and characterize biological pathways that are altered in cancer. In particular, I have been focusing on colorectal cancer. In my work I used various supervised and unsupervised computational methods to analyze high-throughput data suc…
Persistent Aurora (Aur) A and B over-expression, centrosome amplification (CA), chromosomal instability (CIN) and aneuploidy invariably occur together in a vast majority of human neoplasms. These molecular changes are frequently found (>80%) in human sporadic ductal carcinoma in…