Special education has undergone a tumultuous evolution as American society grapples with the most appropriate way to educate students with special needs. Schools and school districts, guided by state and federal regulation, have begun integrating special needs students into gene…
The study seeks to answer how midlife gay men in Manchester manage growing older. It analyses accounts generated through in-depth interviews with 27 middle-aged gay men living in Greater Manchester (aged 39 - 61) and 20 participant observation sessions conducted in Manchester's …
Lysophosphatidic acid (LPA) is known to exert a diverse range of effects in humans, specifically in the heart where it may cause apoptosis of cardiomyocytes at pathological concentrations. However, at physiological concentrations LPA may regulate cell migration, proliferation an…
The differentiation of mesenchymal stem cells (MSCs) to endothelium is a critical but poorly understood feature of tissue vascularisation and considerable scepticism still remains surrounding this important differentiation event. Defining features of endothelial cells (ECs) are …
The biology and ecology of insect parasitoids is strongly influenced by the host-plant species on which their herbivorous hosts occur. Hymenopteran parasitoids in particular, present a series of characteristics that made them good candidates for phenotypic and genotypic differen…
Embryonic stem (ES) cells are a valuable tool for studying differentiation and development (1). These cells are characterized by their potential to differentiate into any of the three germ layers: endoderm, mesoderm and ectoderm (2,3). ES cells are therefore a powerful model sys…
Previous studies in our group revealed the existence of truncated forms of T cell receptor β (TCRβ) mRNA in mesenchymal cells. The expression of truncated TCRβ mRNA was not restricted to mesenchyme. Indeed, such transcripts were found also in the thymus. The present study was ai…
Our understanding of Alzheimer’s disease (AD) pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of AD. It may be possible to overcome these challenges by reprogramming primary cells from patient…