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The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. This publication captures current progress and exci…
Dopamine handbook
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Type: Book
The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspec…
"This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and …
What makes us move? Human movement disorders like Parkinson’s disease have long suggested a vital role for dopamine in movement initiation, but there exists surprisingly little evidence connecting endogenous dopaminergic activity to a causal role in this process. Although “stand…
The prevalence of alcohol use disorder (AUD), a chronic, heterogeneous disease characterized by an escalation from casual alcohol consumption to compulsive alcohol seeking and consumption accompanied by a persistent or recurring negative affective state, is a health crisis occur…
The anterior cingulate cortex (ACC) has been shown to activate when situations are in conflict, when determining the relevance of stimuli, and error processing. Dopaminergic projections to the ACC are hypothesized to facilitate the integration of incoming stimuli with error sign…
The primary cilium is an important sensory organelle present in most mammalian cells. The cilium is involved in regulating various essential cellular processes and by virtue of its structure and location; the most important function of the primary cilium is to act as a sensor. T…
Cognitive dysfunction is a core characteristic of schizophrenia, which can often persist when other symptoms, particularly positive symptoms, may be improved with drug treatment. The non-competitive NMDA receptor antagonist, phencyclidine (PCP), is a psychomotor stimulant drug t…
The loss of control in amounts of drug consumed is a common trait experienced by persons living with drug addiction. The motivation of this dissertation is to further our understanding in the neural mechanisms that mediate consumption of drugs of abuse, to reveal targets for pha…
Dopamine (DA) receptors, members of the G-protein coupled receptors (GPCRs) family, are divided in two groups based on their transmembrane structural homology domains: D1R-like (D1R, D5R sub-types) and D2R-like DA receptors (D2R, D3R and D4R sub-types). Disturbances in dopaminer…
According to the Procedural Deficit Hypothesis, abnormalities in corticostriatal pathways could account for the language-related deficits observed in developmental dyslexia. The same neural network has also been implicated in the ability to learn reinforcement contingencies base…
Humans and animals learn to avoid pain and to seek pleasure. In fact, actions that are essential to the survival of the organism such as mating, eating, and drinking, are invariably pleasurable. The subjective experience of pleasure is typically perceived when engaging the senso…
Repeated exposure to addictive drugs produces neurochemical and structural adaptations in mesolimbic dopamine neurons. It is known that natural motivated behaviors (e.g. feeding, mating) also activate the mesolimbic dopamine pathway. Before the mechanisms underlying drug addicti…
Dopamine (DA) acts centrally through the vasoactive intestinal peptide (VIP) system to stimulate turkey prolactin (PRL) secretion. DA also modulates LH/FSH secretion through gonadotropin-releasing hormone I (GnRH-I) neurons. The distribution of DAergic, VIPergic, and GnRHergic-i…