Background/Significance: Diabetes Mellitus Type 2 (DMT2) is a major chronic condition worldwide. Among Saudi population, it is estimated that 25 % of Saudi adults have DMT2. Diabetes self-Management behaviors (DSMB) and health responsibility (HR) are crucial concepts for people …
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Familial Glucocorticoid Deficiency (FGD) is an autosomal recessive form of adrenal failure characterized by isolated glucocorticoid deficiency with preserved mineralocorticoid secretion. I studied two cohorts of patients who presented with late onset FGD. Firstly I investigated …
Background - The alternatively spliced insulin receptor (IR) exon 11 (36 nucleotides) and the constitutively spliced Apolipoprotein B (APOB) exon 26 (7572 nucleotides) are examples of the shortest and longest exons in the genome. Aim - The aim of this study was to investigate th…
Objectives : Persons with traumatic spinal cord injury (SCI) have severe bone loss below the level of lesion with the distal femur (DF) and proximal tibia (PT) being the skeletal regions appreciated to have the highest risk of fracture. While a reference areal bone mineral densi…
Objectives: Overweight and obesity is linked to several metabolic disturbances including type 2 diabetes. Functional foods such as wheat germ (WG) have been shown to improve metabolic markers in animals and humans alike. Our study investigated the effects of wheat germ supplemen…
Problem: The number of children experiencing precocious puberty has been on the rise — yet the actual cause of this increase is widely understudied and likely multifactorial. From the available research there is an evident link between CNS lesions and organic central precocious …
Juveniles diagnosed with conduct disorder have a history of exhibiting severe maladaptive behaviors. Understanding the contributing factors which influence the mood and behavioral components of conduct disorder would aid in the efficacy of addressing such behaviors. This dissert…
The present study sought to investigate the relationship between of ovarian reserve and immune function. Using data from a subset of 790 nonpregnant, cycling women who were attempting pregnancy between the ages of 30 and 44 participating in the Time to Conceive Study from 2008 t…
An animal’s ability to synchronize life-history events or stages with optimal environmental conditions is paramount to successfully reproducing and maximizing fitness. Additional events including migration, foraging, rearing of young, and emergence from hibernation are all examp…
Loss of fertility as a potential side effect of anti-neoplastic treatments may have a significant negative impact on the survivors’ quality of life. Assisted reproductive technologies (ART) have been adapted and further developed for fertility preservation (FP)and fertility trea…
The human immune system is a vital mechanism that protects the host from outside threats. The two main branches of this system, consisting of innate and adaptive immunity, aid the host when dangers of both imminent and protracted nature occur. Innate lymphoid cells (ILC) play a …
Autosomal recessive spastic ataxia of Charlevoix Saguenay (ARSACS) is an early onset neurodegenerative disorder resulting from mutations in the SACS gene that encodes the protein sacsin. Sacsin is a 520kDa multi-domain protein localised at the cytosolic face of the outer mitocho…
In this body of research, reproductive and adrenal hormones and behavior were used to evaluate individual and group responses to physiological, social, and environmental changes in zoo-housed Asian elephants, considering factors of sex, age, and life stage. Animals experience ph…
Der primäre Hyperaldosteronismus ist die häufigste Ursache einer sekundären Hypertonie. Ein Aldosteronüberschuss kann in vitro und in vivo DNA-Schäden verursachen. In einzelnen Fallberichten wurde über eine Koinzidenz des primären Hyperaldosteronismus mit Nierenzellkarzinomen wi…
Identification of biomarkers that reflect physiological status is fundamental for assessing population health, as well as providing more accurate estimates of life history parameters. Blue (Balaenoptera musculus) and gray (Eschrichtius robustus) whale populations feed on lower t…
The engineering of human reproduction is one of the defining scientific advances of the past century. Methods to specifically engineer the testis have an equally long and rich history, and have experienced significant progress over the past two decades, leading to current-day br…
Introduction: As populations are adopting a Western lifestyle, with high intake of dietary sugar and fat and low physical activity, the risk of developing Type 2 Diabetes is only increasing dramatically. Diabetes leads to drastic alterations within the body, primarily leading to…
Successful reproduction depends upon a highly orchestrated cascade of events during optimal environmental conditions in order to appropriately time ovulation. In spontaneously ovulating rodents, neurons in the hypothalamus secreting gonadotropin-releasing hormone (GnRH) are trig…