Genetic polymorphisms

Aromatic and heterocyclic amine carcinogens found in cigarette smoke and well done meat require host-mediated metabolic activation before initiating tumors in target organs. The N-acetyltransferase isozymes, NAT1 and NAT2, catalyze the activation (O-acetylation) of aromatic and …

Objectives: To examine associations between bladder cancer risk and (1) farming as an occupation, (2) pesticide exposure, and (3) polymorphisms of the GSTM1, GSTT1, NQO1, and SOD2 genotypes among men farmers in Egypt, as well as (4) indirect exposure to farming among women livin…

Breast cancer is major cause of morbidity and mortality globally and the incidence appears to be rising faster in population groups that hitherto experience lower incidence. This case control study recruiting 250 women with breast cancer and 250 age-matched controls from four Un…