Glioma

An emerging hallmark of cancer is the alteration in glucose metabolism that distinguishes most malignant from normal tissues. This calls attention to the importance of understanding the molecular mechanisms by which tumor energy metabolism is regulated. Receptor tyrosine kinase …

Neural stem cells (NSCs) have the capacity to proliferate and give rise to multiple major central nervous system cell types and represent a possible cell of origin in gliomagenesis. Deletion of the tumor suppressor gene Tp53 (p53) results in increased proliferation and self-rene…