Glycosylation

Thirty-five years after its exposure, HIV is still a global health threat with millions of new infections annually. The goal of our research is to stop the global spread of HIV, first by preventing new HIV infections and then by working to cure existing infections. Chapter one r…

N-linked protein glycosylation involves the transfer of a glycan onto an Asparagine residue (N) of a polypeptide chain. It is common in Eukaryotes and has recently been observed in Prokaryotes, most notably in Campylobacter jejuni. The C. jejuni N-linked glycosylation system is …

Comparability assessments are frequently performed during biopharmaceutical drug development to evaluate the effects of manufacturing process changes on the structural integrity, safety and efficacy of candidate protein drug products. Physiochemical analytical evaluations (an es…