haematology

Immune thrombocytopenia is a blood disorder, characterised by low platelet count, bleeding and bruising. In children, symptoms are generally mild and spontaneous remission is common. Literature relating to other paediatric conditions is reviewed and considered alongside limited …

The unfolded protein response (UPR) is a complex signalling pathway activated in response to endoplasmic reticulum stress. In recent years, the UPR has been implicated in cancer and chemosensitivity, particularly in solid tumours. This thesis investigated the potential value of …

Despite improved treatments for Non-Hodgkin’s Lymphoma (NHL) and Multiple Myeloma (MM), most patients eventually relapse and these diseases remain largely incurable. This has precipitated recent research into more clinically relevant in vitro models to enable development of more…