Heart disease is responsible for one in four deaths in the United States. Atherosclerotic Cardiovascular Disease (ASCVD) screening tools can help with risk stratification and treatment of low, intermediate, and high-risk patients before an event such a myocardial infarction or s…
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Sudden cardiac death (SCD) is estimated to cause 300,000 deaths per year. Almost half of those that occur in young, otherwise healthy individuals are found to have a family history of a “warning sign” of SCD. An arrhythmia syndrome (ARS) should be considered if sudden infant dea…
Cardiovascular disease is the leading cause of death in patients with underlying chronic kidney disease (CKD). Up to one third of patients presenting with an acute coronary syndrome have CKD stage 3-5. Outcomes following acute myocardial infarction in patients with underlying CK…
Desmosomes are macromolecular, dynamic and adaptable complexes that connect intermediate filaments of neighboring cells in a variety of tissues, generating a large mechanically resilient structure. The importance of maintaining desmosome homeostasis for tissue integrity and opti…
Ingestion of vegetables rich in inorganic nitrate (NO3-) content has emerged as an effective method, via the formation of a nitrite (NO2-) intermediate, for acutely elevating vascular nitric oxide (NO) levels. As such a number of beneficial effects of NO3- ingestion have been de…
Background: Recent studies have revealed an association between genetic variants at the ADAMTS7 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 7) locus and susceptibility to coronary artery disease (CAD). ADAMTS-7 has been reported to facilitate vascul…
Cardiovascular disease is the leading cause of unnatural death worldwide. Damage to the endothelial glycocalyx impairs endothelial functions and thereafter leads to the development of cardiovascular diseases. Despite this, many issues remain to be explored in our understanding o…
Catheter ablation complex or fractionated atrial electrograms (CFAE) may improve outcomes for persistent AF. However, it is unclear whether CFAE are important in maintaining AF or whether targeting of CFAE can be refined based on electrogram morphology or knowledge of the remode…
Ischaemic heart disease is the most common cause of mortality in the western hemisphere and it is rapidly becoming the leading cause of death globally. Moreover, therapeutic interventions by cardiologists and cardiac surgeons frequently subject the heart to acute I/R injury, whi…
Background Non-adherence to evidence based secondary prevention medicines (SPM) by coronary heart disease (CHD) patients limits their expected benefits and may result in a lack of improvement or significant deterioration in health. This study explored self-reported non-adherence…
Background: The mortality rates of coronary artery disease (CAD) have declined in the past three decades in the United States (US). However, the rates of decline are slower for racial and ethnic minority populations including South Asians (SAs). Increased premature incidence and…
Heart failure is a major health problem of epidemic proportions. The upregulated expression of endothelial cell adhesion molecules in certain regions of the heart after a myocardial infarction (MI) provides a potential avenue for selectively targeting drugs to inflamed tissue. L…
Evidence shows that omega-3 fatty acids (n-3 FAs) may help in preventing heart disease. The purposes of this current study were to investigate the consumption and the food sources of n-3 FA in two groups of elderly men living in different geographic location (coastal and interna…
Many studies have recently shown that hyperhomocysteinemia (H-Hcy) is a very well recognized risk factor for CHD. It is believed that folate status is the major determinant of Hcy levels. The objectives of the present study were to investigate folate and vitamin B12 status in Jo…