Approximately 6 million Americans have heart failure with treatment costs estimated at 30.7 billion annually. Those in late stages of the disease experience profound physical, emotional, and spiritual suffering. Spiritual wellbeing has been linked to quality of life as well as m…
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Heart disease remains the leading cause of death in the United States, but technology (e.g., pacemakers, defibrillators, and imaging systems) has dramatically lowered mortality associated with heart disease. In basic research science, integrative approaches with different tools …
Introdução : A espiritualidade é o aspeto da humanidade que se refere à forma como os indivíduos procuram e expressam sentido e propósito e está frequentemente relacionada com o significante ou sagrado. A espiritualidade torna-se particularmente importante nos cuidados em fim de…
Contraction in striated muscle is regulated by Ca+2 through the tropomyosin (Tm)-troponin (Tn) thin filament associated regulatory complex. The Tn complex is composed of three subunits: troponin C (TnC), troponin I (TnI), and troponin T (TnT). Troponin T has been proposed as a m…
The incidence of congestive heart failure (CHF) rises annually and, despite advances in medical treatments, the prognosis remains poor. Since CHF has no cure, the treatment is mostly supportive symptom management and prevention of exacerbation. Studies examining the impact of so…
Targeting of the narrow therapeutic index (NTI) drug warfarin is very challenging for patients and physicians alike. That's because subtherapeutic warfarin level can cause recurrence of the thromboembolic events while supratherapeutic level may significantly raise the bleeding r…
Splicing factors bind, in most cases, to a degenerate motif in the pre-mRNA of the target gene and either recruit or repel the spliceosome to/from nearby splice sites. Many splicing factors possess RNA-independent functions, such as protein-protein interactions in cellular compl…