Purpose: Gastric cancer is responsible for about 1 million incident cancer cases and 750,000 cancer deaths annually, half of which occur in East Asia. Survival is low because the disease is usually diagnosed at late stage when treatment is difficult. However, early stage disease…
Most patients colonized by H. pylori remain asymptomatic. Many patients complain of dyspepsia, but any association with H. pylori colonization remains controversial. About 20% of colonized individuals develop duodenal or gastric ulcers and some develop gastric cancer. Urease, li…
The gene MUC1 encodes a transmembrane mucin glycoprotein that is expressed on the apical surface of most epithelia and is aberrantly expressed in cancer. MUC1 contains an extended domain of tandemly repeated (TR) amino-acid sequence, which acts as the backbone for a large amount…
