An integrated, multidisciplinary account of the virus, its biology and clinical manifestations.
People who inject drugs (PWID) is a heterogeneous and hard-to-reach group due to legal implications, stigma and discrimination. PWID are vulnerable to various poor health outcomes including HIV and hepatitis due to ongoing injection and sexual risk behaviours, various forms of a…
Background: Globally, injection drug use (IDU) is common among cisgender women who participate in sex work (CWSW), placing them at heightened risk of HCV acquisition and transmission. However, the epidemiology of HCV among CWSW in the United States is not well understood. In thi…
Background: Hepatitis C virus (HCV) infection is the most prevalent bloodborne viral infection nationally. Injection drug use is the most commonly reported mode of transmission and incident cases of acute HCV infection have more than quadrupled between 2010 and 2018. This increa…
Hepatitis C is a blood borne virus affecting the liver. In the UK, approximately 214,000 people are infected with the hepatitis C virus. Hepatitis C disproportionally affects marginalised populations and in the UK sharing equipment used to inject drugs is the main risk factor fo…
Population health has drastically changed over time, especially in countries like China where rapid economic and social growth has occurred in the past decades. Economic development in China was paralleled with increase alcohol consumption and an increasing burden of chronic dis…
Chronic hepatitis C (CHC) is a leading cause of hepatic fibrosis and cirrhosis. Fortunately, treatment has been revolutionized by the recently introduced direct-acting antivirals (DAAs). However, prompt access to DAA therapy remains a challenge owing to exorbitant drug costs, as…
This thesis aims to present the case for establishing a routine service for testing and treatment of hepatitis C (HCV) for people prescribed opioid substitution therapy (OST) and attending community pharmacies. In order to support its contention, it reports on the methodological…
Chronic infection with the hepatitis C virus infection (HCV) affects over 170 million individuals worldwide. In this thesis the natural history and management of hepatitis C in North- East London was investigated. The prevalence of cirrhosis in patients with chronic hepatitis C …
Hepatitis C im Dialog: 100 Fragen - 100 Antworten
With the development of robust cell-culturing systems capable of Hepatitis C Virus replication and infection, the past decade has witnessed an explosion of innovative research directed at understanding HCV biology in the context of the authentic replicative cycle of the virus. B…
Globally, men who have sex with men (MSM) continue to be disproportionately affected by the HIV pandemic. However, prior to this study, very little was known about the magnitude and factors that heighten MSM's vulnerabilities to HIV and other STIs in Nigeria. A cross-sectional s…
A case-control study was conducted to investigate the association between non-Hodgkin's lymphoma and infection with hepatitis C virus (HCV) in a population of Egyptian adults. Between 1999 and 2001, I29 NHL cases and 18I controls with other cancers were recruited from a major ca…