Inositol

Signalling by inositides: a practical approach

by Shears, Stephen

fromPractical Approach Series

0 Type: Book

"Inositide research has infiltrated numerous branches of biochemistry, physiology, and molecular biology. Consequently, methodological information has been scattered far and wide. This book unites a wide selection of the most fundamental and commonly used techniques. Contributor…

Signalling by inositides: a practical approach

by Shears, Stephen

fromPractical Approach Series

0 Type: Book

"Inositide research has infiltrated numerous branches of biochemistry, physiology, and molecular biology. Consequently, methodological information has been scattered far and wide. This book unites a wide selection of the most fundamental and commonly used techniques. Contributor…

Signalling by inositides: a practical approach

by Shears, Stephen

fromPractical Approach Series

0 Type: Book

"Inositide research has infiltrated numerous branches of biochemistry, physiology, and molecular biology. Consequently, methodological information has been scattered far and wide. This book unites a wide selection of the most fundamental and commonly used techniques. Contributor…

The phosphatidylinositol polyphosphates play a fundamental role in intracellular signalling. Of particular importance is phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P₃], which acts by recruiting effector proteins to the cell membrane. PtdIns(3,4,5)P₃ interacts with it…

The intracellular second messenger InsP₃ is a vital molecule in the regulation of Ca²⁺ signalling. Ca²⁺ mediates a wide range of cellular activities from fertilisation and cell differentiation through to apoptoisis. Using X-ray crystal structure data and molecular modelling, a s…