Gestational diabetes mellitus and hypertensive disorders in pregnancy are serious maternal health conditions with immediate and lifelong mother-child health consequences. These obstetric pathologies have been widely investigated, but mostly in silos, while studies focusing on th…
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Metabolic syndrome (MetS) is a cluster of symptoms that increase risk for heart disease and type 2 diabetes. Therefore, early detection of MetS is vital for disease prevention. Gestational diabetes (GDM) and/or obesity during pregnancy are associated with a greater risk for MetS…
Type 2 diabetes (hereafter, diabetes) and prediabetes are very common in older adults and constitute a great health concern for this population. The objective of this project is to investigate the impact of prediabetes and diabetes on health and survival among older adults, and …
Life history theory dictates that organisms should precisely allocate investment of their limited resources, including energy, to a variety of tasks to serve natural selection’s ultimate goal: reproduction. In adolescence, menarche occurs as growth velocity is tapering off, prov…
Diabetes mellitus, commonly referred to as “diabetes,” is characterized as elevated blood glucose levels resulting from the body’s inability to produce insulin or cells’ compromised sensitivity to insulin. Type 2 diabetes is a compromised sensitivity to insulin or insulin resist…
The overall aim of the work presented in this thesis was to further characterise aspects of metabolic and immune system cross-talk in human subcutaneous adipose tissue, with a particular emphasis on the potential role of T-lymphocytes in adipose tissue dysfunction and insulin re…
Background and objective: Childhood obesity is a serious global health problem and it is associated with insulin resistance and significantly increased risk for development of type 2 diabetes and cardiovascular disease. Metformin reduces the risk of developing T2D in adult patie…
For over 50 years, Americans were led to believe that diets high in carbohydrates but low in dietary fat was healthy and normal. Now, over 34 million Americans are diagnosed with diabetes, 95% of that population having Type 2 Diabetes Mellitus (T2DM). Insulin resistance is a kno…
Introducción: El síndrome metabólico (MetS) es un conjunto de trastornos que incluyen a la obesidad visceral o abdominal, la hipertensión arterial, la hipertrigliceridemia, el colesterol HDL bajo y la hiperglicemia. Ante la presencia de tres o más de los cinco criterios definido…
A number of challenges or perturbations in metabolic pathways lead to significant increases in plasma and tissue long-chain acylcarnitines (LCAC). The LCAC and other acylcarnitines rise, for instance, in the blood and muscle during exercise bouts, as tissue acyl-CoA pools change…
Whole yellow pea flour (WPF) and fractionated yellow pea flour (FPF) are novel functional food ingredients that vary in nutritional composition. Consequently, the health benefits of WPF and FPF remain undefined. The purpose of this research was to identify the effects of WPF and…
In recent years, studies have revealed a central role for the intestine in regulation of lipid homeostasis and development of insulin resistance and type-2 diabetes. The function of intestinal Scavenger Receptor Class-B type-I remains unknown, however it is believed to play a ro…
Conjugated linoleic acid (CLA) refers to all the positional and geometric isomers of linoleic acid. The two most studied isomers are cis 9, trans 11-CLA and trans 10, cis 12-CLA. CLA supplements, often a mixture of the two isomers, have been popularly used for weight loss and ot…
Control of gene transcription is a powerful tool by which cells respond to their external environment. The dynamic nature of muscle tissue is controlled largely by gene expression changes, however the specific mechanisms by which these changes occur and lead to altered muscle si…
South Asians are people with origins in India, Pakistan, Bangladesh, Sri Lanka, Nepal, Bhutan, and the Maldives. In the United States (US), South Asians are among the fastest growing ethnic/immigrant groups with a growth rate of 70% from the 2000 to the 2010 Census, now consisti…
Amaç Çalışmamızdaki amaç, zebra balığında fazla beslenme ile oluşturulan tip 2 diyabet modelinde Stevia rebaudiana’nınolası etkisinin incelenmesidir. Gereç ve Yöntem Yetişkin zebra balıkları 15 gün boyunca fazla beslenmeye ve Stevia rebaudiana’nın düşük ve yüksek olmak üzere iki…
Amaç: Son yıllarda yapılan çalışmalar Myrtus Communis L. (MC) ekstraktının antioksidan ve antidiyabetik özelliklerini ortaya koymaktadır. Bu çalışmadaki hedefimiz bu ekstraktın yüksek yağlı diyet (YYD) ile beslenen sıçanların pankreası üzerinde etkilerini ortaya koyabilmektir. G…