This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play…
The range of conformational states that determine the function of a protein is often unknown. This is the case for most proteins. In particular, for membrane proteins, this is more challenging, as their structures are often difficult to resolve. At present, the computational pre…
This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion a…
Calcium Measurement Methods
by Verkhratsky, Alexei, Verkhratskii, A. N, Petersen, O. H, Verkhratskiæi, A. N.
fromNeuromethods
Since the introduction of fluorescent calcium indicators and the subsequent development of capacities for real-time monitoring and imaging of calcium movements in the intact cells studied in isolation, in situ and in vivo, the complex and vital calcium signalling system has been…
Since the introduction of fluorescent calcium indicators and the subsequent development of capacities for real-time monitoring and imaging of calcium movements in the intact cells studied in isolation, in situ and in vivo, the complex and vital calcium signalling system has been…
The subject of this dissertation is modeling and analysis of diffusion phenomena in confined domains, which arise in molecular biophysics. The specific process that motivates this research are selectivity in ion channels and synaptic transmission in neurons.
Stimulus-secretion coupling in the pancreatic beta cell is mediated by different signalling molecules and involves a variety of ionic events including Ca2+-influx through voltage-gated Ca2+ channels and Ca2+ mobilization from intracellular stores. Inositol 1,4,5-trisphosphate (I…
Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book disc…
Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book disc…
Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book disc…