Isomérisation

Upon treatment with a palladium catalyst and hydrogen gas in the presence of caesiumcarbonate, a wide range of exomethylenic allylic alcohols were found to afford theircorresponding trisubstituted isomers. Although hydrogenation was an unavoidablecompeting pathway, careful monit…

This thesis is focused on an investigation of the mechanisms of three enzymatically mediated carbon skeleton isomerisation reactions. Chapter 1 provides an overview of some representative examples of the carbon skeleton rearrangement reactions in enzymology. Chapter 2 describes …