This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great…
Life-philosophy, central to nineteenth-century philosophical thought, is concerned with the meaning, value and purpose of life. This much-needed study returns to the central philosophical questions of Lebensphilosophie and reveals the ascendency of ‘life’ in contemporary philoso…
This volume systematically guides readers through the process of writing scientific papers for submission to peer-reviewed journals, and addressing referees' responses. Beyond merely listing elements required for successful scientific writing, A Scientific Approach to Scientific…
Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make…
"This book contains a collection of protocols and techniques to analyze in vivo trafficking of endocytic/endosomal cargo, including lipids, fluids, proteins, and ligands, ultrastructural features of endosomes by high-pressure freezing/freeze-substitution and electron tomography,…
The Cult of Statistical Significance shows, field by field, how "statistical significance," a technique that dominates many sciences, has been a huge mistake. The authors find that researchers in a broad spectrum of fields, from agronomy to zoology, employ testing that doesn't "…
The Cult of Statistical Significance shows, field by field, how "statistical significance," a technique that dominates many sciences, has been a huge mistake. The authors find that researchers in a broad spectrum of fields, from agronomy to zoology, employ testing that doesn't "…
This book introduces the basic techniques and methods traditionally used in speaking about science to the public. The public often has a very different perception and understanding of science, and this must be taken into account when communicating with the public. This volume co…
This book advances a recent historiographical turn towards the intersection of early modern philosophy and the life sciences by bringing together many of its leading scholars to present the contributions of important but often neglected figures, such as Ralph Cudworth, Nehemiah …
This is the first book in longitudinal categorical data analysis with parametric correlation models developed based on dynamic relationships among repeated categorical responses. This book is a natural generalization of the longitudinal binary data analysis to the multinomial da…
In this book the authors examine the history of innovation in the biosciences, tracing technological innovation from the late eighteenth century to the present and placing special emphasis on how and where technology evolves. Place is often key to innovation, from the early indu…
This book presents the most recent mathematical approaches to the growing research area of networks, oscillations, and collective motions in the context of biological systems. Bringing together the results of multiple studies of different biological systems, this book sheds ligh…
This book provides a theoretical background of branching processes and discusses their biological applications. Branching processes are a well-developed and powerful set of tools in the field of applied probability. The range of applications considered includes molecular biology…
Through refereed papers, this volume focuses on the foundations of the Bayesian paradigm; their comparison to objectivistic or frequentist Statistics counterparts; and the appropriate application of Bayesian foundations. This research in Bayesian Statistics is applicable to data…
This volume seeks to enable the discovery of tools in chemical biology by providing readers with various techniques ranging from initial chemical genetic screening to target identification. To successfully highlight the essential components of the chemical biology tool discovery…
"This volume includes comprehensive and up-to-date coverage of all nucleic-acid-specific steps used in X-ray crystallography, from macromolecule production to structure determination. Chapters dedicated to RNA preparation and crystallogenesis will be of interest to beginners, wh…
