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Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment …
This book will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in drug discovery techniques.
Textbook of receptor pharmacology
by Foreman, John C., Johansen, Torben, Gibb, Alasdair J.
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Type: Book
Providing an introduction to the study of drug receptors, the Textbook of receptor pharmacology discusses quantitative descriptions of functional studies with agonists and antagonists; quantitative descriptions of ligands binding to receptors; the molecular structures of drug re…
This volume provides a collection of protocols and approaches for the creation of novel ligand binding proteins, compiled and described by many of today's leaders in the field of protein engineering. Chapters focus on modeling protein ligand binding sites, accurate modeling of p…
Computational design of ligand binding proteins
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Type: Book
This volume provides a collection of protocols and approaches for the creation of novel ligand binding proteins, compiled and described by many of today's leaders in the field of protein engineering. Chapters focus on modeling protein ligand binding sites, accurate modeling of p…
This volume provides a collection of protocols and approaches for the creation of novel ligand binding proteins, compiled and described by many of today's leaders in the field of protein engineering. Chapters focus on modeling protein ligand binding sites, accurate modeling of p…
This volume provides a collection of protocols and approaches for the creation of novel ligand binding proteins, compiled and described by many of today's leaders in the field of protein engineering. Chapters focus on modeling protein ligand binding sites, accurate modeling of p…
Chemists must consider the importance of ligands in transition metal complexes used as catalysts-- including selectivity and reactivity characteristics and how to choose different ligands in order to perform practical and efficient synthesis. This book serves as a manual for syn…
Serving as a user's manual for synthetic organic and catalytic chemists, this book guides chemists in the design and choice of ligands to catalyze organic reactions and apply the results for more efficient, green, and practical synthesis. Focuses on the role of ligands in metal …
Serving as a user's manual for synthetic organic and catalytic chemists, this book guides chemists in the design and choice of ligands to catalyze organic reactions and apply the results for more efficient, green, and practical synthesis. Focuses on the role of ligands in metal …
Structure and bonding -- Dative liquids -- Covalent (X type) ligands bound through metal-carbon and metal-hydrogen bonds -- Covalent (X type) ligands bound through metal-heteroatom bonds -- Ligand substitution reactions -- Oxidative addition of nonpolar reagents -- Oxidative add…