Lyme Disease

Zoonotic diseases, diseases that can be transmitted between humans and animals which account for the majority of emerging infectious diseases, pose a consistent health burden on the human population. Transmission of zoonotic pathogens is driven by a complex interface between hum…

Borrelia burgdorferi, a bacterium which causes Lyme disease, is maintained in nature through a cycle involving two distinct hosts: a tick vector and a mammalian host. To adapt to these two diverse environments, B. burgdorferi undergoes dramatic alterations in its surface lipopro…