Background: Anthropometric measures including birth weight and body mass index have been associated with adult periodontal disease. However, thre is limited evidence regarding the role of childhood growth in subsequent periodontal inflammation.
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Primary Sjögren’s syndrome is a systemic autoimmune disease primarily affecting salivary and lacrimal glands, but patients may also have other organ involvement. Development of Sjögren’s syndrome has been associated with genetic polymorphisms and aberrances in innate and adaptiv…
The overall aim of the work presented in this thesis was to further characterise aspects of metabolic and immune system cross-talk in human subcutaneous adipose tissue, with a particular emphasis on the potential role of T-lymphocytes in adipose tissue dysfunction and insulin re…
Introduction: Type 1 diabetes is an autoimmune condition that results in the inability of the pancreas to produce insulin. The mainstay of treatment for this disease is administration of exogenous insulin. Adherence to this therapy is vital in avoiding both life-threatening shor…
Homeostasis of the immune system is required for proper defense against pathogenic insult. Cells of the innate and adaptive compartments provide a strictly regulated response to clear infections while allowing for self-tolerance. Dysregulation of the components of the immune sys…