Background:Parkinson’s disease (PD) is a neurodegenerative disease characterized by rigidity, hypokinesia, tremor and postural instability. PD is a clinical diagnosis based on neurological examination, patient history and treatment response. Similar symptoms can be caused by oth…
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Moyamoya (MMA) is a progressive cerebral steno-occlusive angiopathy which can lead to strokes. Its natural history derives from adult East Asian cohorts with idiopathic disease. Clinical differences in pediatric, non-Asian and syndromic patients are reported but understudied. Th…
Endovascular intervention has largely replaced the use of open vascular surgery. These treatments have multiple decisions that are made largely through clinician experience and qualitative inference of two- (and increasingly three-) dimensional image data. This has yielded excel…
The sodium iodide symporter (NIS) transports iodide, which is necessary for thyroxine production. NIS is also a powerful transgene used to track the in vivo spread of oncolytic viruses, gene therapies, and transplanted cells via uptake of radiotracers into infected or transduced…
Abdominal aortic aneurysms (AAA) is a dilation of the abdominal aorta, typically within the infra-renal segment of the vessel that cause an expansion of at least 1.5 times the normal vessel diameter. It is becoming a leading cause of death in the United States and around the wor…
Purpose: Computed tomography (CT) has the highest sensitivity and specificity for urolithiasis in patients with acute flank pain. However, some studies have suggested that ultrasound (US) should be the initial imaging test in the Emergency Department (ED) for suspected urolithia…
Breast cancer is currently the most prevalent form of cancer in women with over 266,000 new diagnoses every year. The various methods used for breast cancer screening range in accuracy and cost, however there is no easily reproducible, reliable, low-cost screening method current…
Black women are starting to be recognized as a high-risk group for breast cancer. In addition to Black women having a relatively high incidence rate and the highest mortality rate, Black breast cancer patients were found to have an alarming rate of the BRCA1/2 genetic mutation. …
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and associated with increased risk for ischemic stroke and mortality. While the risk of stroke has been shown to be reduced with the use of oral anticoagulants like Warfarin, these medications are predictably linked…
Introduction: As populations are adopting a Western lifestyle, with high intake of dietary sugar and fat and low physical activity, the risk of developing Type 2 Diabetes is only increasing dramatically. Diabetes leads to drastic alterations within the body, primarily leading to…
This engaging book covers a multitude of topics related to heart rhythm disorders (HRDs) and uniquely familiarizes readers with the development of treatment modalities over the past several decades, including the evolution of anti-arrhythmic drugs, pacemakers, defibrillators, an…
Medical volume segmentation got the attraction of many researchers; therefore, many techniques have been implemented in terms of medical imaging including segmentations and other imaging processes. This research focuses on an implementation of segmentation system which uses seve…
Introduction: Sleep apnea is an under recognized systemic condition with a variety of cardiovascular, ocular, and psychosocial complications. This records review was conducted to validate the clinical observation of an association between far peripheral retinal hemorrhages and s…
Pancreatic Cancer is one of the lethal cancers in the world with vague symptoms and low survival rates. It is the seventh leading cause of cancer-related deaths in the world and will become the second within 2030 in USA. The five (5) years survival rate for all stages diagnosed …
The aim of this dissertation is to determine whether depression is associated with clinical (relapses and disability worsening) and MRI outcomes in multiple sclerosis (MS) by conducting a secondary data analysis of the CombiRx clinical trial. Psychiatric comorbidities, including…
Since the earliest days of dental radiography, projection imaging has been the primary means of radiographic assessment during routine examination of the dentition. The sensitivity for carious lesion detection through projection imaging, hovering no higher than about 65%, leaves…
With age, muscle mass decreases and muscle function and strength decline, which is associated with loss of independence, hospitalization, morbidity and mortality. The aim of this thesis was to investigate the mechanisms involved in the age-related loss of muscle mass, physical f…