Medicinal Chemistry

This thesis is focused on the development of new catalytic tools to access complex structural scaffolds with a special emphasis given to heterocyclic compounds. The first chapter presents our work in the field of DNA-based asymmetric catalysis. After presenting how the DNA doubl…

Chapter 1 gives an overview of the fluorine chemistry field, from its early developments to recent applications in medicinal chemistry. The development of asymmetric electrophilic or nucleophilic installation of fluorine in organic molecules is highlighten. Chapter 2 of this the…