Microglia

Viral infections require a delicate balance of pro- and anti-inflammatory factors in order to clear infection while causing minimal immunopathology. A number of coronavirus infections disrupt this balance to cause substantial immunopathology, including JHMV, a neurotropic strain…

Aging, defined as the increasing probability of mortality over time due to organismal declines in function, is the leading risk factor for cognitive decline and associated dementias. In adults 45 years of age and older in the United States (U.S.), subjective cognitive decline is…

In recent years, infant pain research has revealed strong evidence that pain history impacts sensory processing in adulthood. It has become clear that (1) somatosensory processing in the neonatal CNS differs substantially from that in adults both in terms of structure and functi…

Adult neurogenesis is the most dramatic form of plasticity in the adult brain and may play a role in learning and memory, especially in perceptually difficult tasks in complex natural environments. New neurons appear only in a few regions of the adult mammalian brain and become …