Hyde's Introduction to Genetics teaches the principles of genetics with an innovative approach that emphasizes the basic concepts involved in solving problems as well as teaching students how to manipulate genetic data.
During mitosis, accurate chromosome segregation is essential: gain or loss of genetic information can be detrimental to cell viability, or promote tumourigenesis. The mitotic checkpoint (also known as the spindle assembly checkpoint or SAC) ensures accurate chromosome segregatio…
Mutations in the STAG2 gene are present in approximately 20% of tumors from different tissues of origin. STAG2 encodes a subunit of the cohesin complex, and tumors with loss of function mutations are usually aneuploid and display elevated frequencies of lagging chromosomes durin…
Initiation of protein synthesis in the eukaryotic cell proceeds by two major mechanisms: "cap-dependent" mode, which involves the assembly of the pre-initiation complex at the 5' cap m7GpppX structure in the mRNA and the "cap-independent" mechanism, in which the ribosome lands d…