Chemotherapy-induced oral mucositis is an undesirable effect of chemotherapeutic drugs and is a consequence of the direct action of these drugs on the oral mucosa. The most widely used conditioning regimen in multiple myeloma patients undergoing autologous hematopoietic stem cel…
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The immune system, made up of an innate and an adaptive arm, is a complex yet elegant system through which host defense against foreign pathogens is provided. The understanding of this intricate network of cells and soluble factors and how normal immune homeostasis is reached is…
"The intent of this book is to present a methodology for the formulation and computer implementation of mathematical models for multiple myeloma, a form of bone cancer. The models are stated as systems of ordinary and partial differential equations (ODE/PDEs). The ODE/PDE method…
Multiple myeloma is a form of bone cancer. Specifically, it is a cancer of the plasma cells found in bone marrow (bone soft tissue). Normal plasma cells are an important part of the immune system. Mathematical models for multiple myeloma based on ordinary and partial differentia…
Although there is no therapy that could be considered curative for patients with multiple myeloma, recent research has gained considerable momentum and yielded a real prospect for achieving a significant improvement in response to therapy. In Multiple Myeloma: Methods and Protoc…
A comprehensive collection of classic and innovative methodologies used in many laboratories for the investigation of multiple myeloma. These readily reproducible techniques range from the standard Plasma Cell Labeling Index methodology to a final chapter on making sense of micr…
Despite improved treatments for Non-Hodgkin’s Lymphoma (NHL) and Multiple Myeloma (MM), most patients eventually relapse and these diseases remain largely incurable. This has precipitated recent research into more clinically relevant in vitro models to enable development of more…
Therapeutic options for patients with myeloma have radically changed over the past ten years. Beginning with the advances in therapy resulting from the use of high dose therapy and autologous bone marrow or stem cell transplant, we have more than doubled the median survival for …
Therapeutic options for patients with myeloma have radically changed over the past ten years. Myeloma Therapy: Pursuing the Plasma Cell provides various updated treatment options for patients with myeloma, with focus on the emerging and speculative aspects of myeloma therapy. Wr…