This work discusses the history of a genetic mutation, discovered in 1959, that causes chronic myeloid leukemia, and traces the research and breakthroughs that led to the creation of a drug that makes this once-fatal illness now treatable. It focuses on what is widely viewed as …
The thale cress Arabidopsis thaliana is increasingly popular among plant scientists: it is small, easy to grow, and makes flowers, and the sequence of its small and simple genome was recently completed. This is the most complete and authoritative laboratory manual to be publishe…
Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations…
Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnbosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutation…
Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations…
While European restaurants race to footnote menus, reassuring concerned gourmands that no genetically modified ingredients were used in the preparation of their food, starving populations around the world eagerly await the next harvest of scientifically improved crops. Mendel in…
Melanoma accounts for the majority of the mortality from all types of skin cancers. Five to ten percent of the cases are familial melanoma, yet more than 50% of the melanoma families cannot be explained by established susceptibility genes. By understanding the genetics behind un…
Insecticide application via indoor residual spraying (IRS) and long-lasting insecticide-treated bednets (LLIN) has been a key component in combating malaria in sub-Saharan Africa, with pyrethroids being the traditionally recommended insecticides. However, the resistance of Anoph…
Background: African Heritage (AH) men have a higher overall incidence, earlier age of onset, more clinically advanced and aggressive disease, higher incidence of metastases and mortality from prostate cancer (CaP) compared to Caucasian men. Biological and genetic factors relatin…
Pancreatic Cancer is one of the lethal cancers in the world with vague symptoms and low survival rates. It is the seventh leading cause of cancer-related deaths in the world and will become the second within 2030 in USA. The five (5) years survival rate for all stages diagnosed …
This thesis describes a new disease encompassing infantile-onset movement disorder (including severe parkinsonism and nonambulation), mood disturbance, autonomic instability, and developmental delay that was identified in eight cousins of a consanguineous Bedouin family in Saudi…
Astrocytes maintain ion and neurotransmitter homeostasis within the central nervous system. They do so by expressing channels, receptors and transporters such as excitatory amino acid transporters (EAATs) along their highly ramified arbours. EAATs are well known to be glutamate …
Mutations in the human and mouse Ostm1/Ostm1 gene result in the most severe form of autosomal recessive osteopetrosis, an inherited hematopoietic bone disorder. We isolated and characterized the Ostm1 gene responsible for the spontaneous murine osteopetrotic gl mutation and func…
Feature selection aims to gain a minimal feature subset in a problem domain while conserving the accuracy of the original data. Feature selection is a process for making more efficient data analysis by selecting more relevant features for the related problem solving. Feature sel…
