Mycobacterium tuberculosis

Tuberculosis has been an important disease throughout human history, shaping countless past populations. The archaeological study of the causative agents of tuberculosis, members of the Mycobacterium tuberculosis Complex (MTBC), is hindered by the non-diagnostic nature of tuberc…

M. tuberculosis has persisted as one of the most prevalent and deadly human pathogens in large part because of its ability to evade the host immune system. In addition to several cellular based evasion mechanisms have been described, the adaptive immune response to M. tuberculos…

Before the emergence of SARS-CoV-2 and the ensuing COVID-19 pandemic, the pathogenic bacteria Mycobacterium tuberculosis was the world’s leading infectious disease killer. In 2020, an estimated 1.6–1.8 million people worldwide died of tuberculosis (TB) disease, comparable to the…

The tuberculin skin test (TST) is the standard test for detecting latent tuberculosis infection. With the HIV epidemic and the resurgence of tuberculosis (TB), identifying and treating persons with latent infection has been found to be important to prevent the development of act…

A relatively large genome, predicted to encode more than 4200 bacterial factors functions to allow Mycobacterium tuberculosis to survive and grow within a variety of different environments encountered during the progressive course of human infection. Among the different environm…