A classic among NMR textbooks, this thoroughly enlarged and updated fourth edition contains a new treatment applications of Magnetic Reconance Tomography and Magnetic Resonance Spectroscopy, describes polymer solid state NMR and analysis of biopolymers.
This thesis describes the isolation and structure elucidation of secondary metabolites from a number of endophytic Xylaria fungi. Six Xylaria endophytes were surface cultured on an aqueous malt extract-glucose medium. The fungus A311R, from a palm tree in Thailand, produced nona…
The bis-naphthalimidopropyl drugs DMP8408, BNIPDaoct and BNIPDanon, have been developed as novel synthetic lead compounds in cancer therapy. Biochemical assays of these compounds have demonstrated high inhibitor activity (IC50=0.8–1.8μM) against cancer cells, which makes them th…
The ability of surfactants to form micelles and solubilise hydrophobic substances in aqueous environments has been widely exploited in formulation science. In spite of extensive studies over the past few decades by both experimental and theoretical methods, however, it remains d…
Type IV pili, or fimbriae, are long, thin proteinaceous appendages found on the surface of many well-known pathogens. They mediate a variety of important virulence functions for the organism, such as twitching motility, biofilm formation, uptake of genetic material and host cell…
Computational modelling of chemical systems is most easily carried out in the vacuum for single molecules. Accounting for environmental effects accurately in quantum chemical calculations, however, is often necessary for computational predictions of chemical systems to have any …
The paralogous multi-functional adaptor proteins YAP and TAZ are nuclear effectors of the Hippo pathway, a central regulator of developmental organ size control, tissue homeostasis and tumour suppression. YAP/TAZ target the TEAD transcription factor family to promote cell surviv…
In this project a number of peptidyl transferase antibiotics were studied, specifically a group of aminohexose cytosine nucleoside antibiotics and their interaction with a selected number of highly conserved ribonucleic acid (RNA) motifs, designed to represent their possible bin…
Many thousands of pounds are spent every year by pharmaceutical companies on understanding the mechanisms and kinetics of chemical reactions involved in drug discovery and production. NMR spectroscopy is often at the core of these studies as it is a powerful, non-destructive met…
"The book is primarily designed for students to be used during courses and exercises. The use of the book requires only basic knowledge of spectroscopic techniques, but is structured in such a way that it will support practitioneers routinely faced with the task of interpreting …
The history of the World could not be told without mentioning specialized metabolites. Long before we had the notion of organic molecules, we were already sailing across the oceans in the pursue of their valuable sources, and raising whole empires based on the economy of spices,…
The area of art conservation presents many interesting problems in analytical chemistry. This work describes studies of four applications of nuclear magnetic resonance to problems in art conservation. A new double quantum filtered internal DOSY NMR experiment was developed and t…
This dissertation presents three methods for evaluating formation permeability using log data in the CTR field, Saudi Arabia. The first method used the concept of hydraulic flow units (HFU's). The second method derived formation permeability using neural networks and log data. T…
In this dissertation, the problem of the Joint Time-Frequency (JTF) transforms is addressed with the objective of developing linear critically-sampled JTF transform with optimal characteristics, namely being stable and having the biorthogonal function and the analysis function b…
Thiosemicarbazones are a class of compounds which have been extensively studied for their anti-proliferative biological properties. The biological properties include antitumor, antibacterial, antiviral and antimalarial, with many diseases studied and reported in the literature. …
Roemeria refracta of Turkish origin had formerly provided a number of alkaloids suspected of belonging to the pavine-isopavine grouping. As a result of the present effort, it was demonstrated that one of these bases, (-)-eschscholtzinone, is the first ketonic pavinoid. (-)-Norre…
