An introduction to the chemical and biological properties of alkaloids isolated from M. speciosa as well as their synthetic analogues. The book covers various topics including phytochemistry, medicinal chemistry, and pharmacology. Current research, analgesic effects, and addicti…
Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a single source: the opium poppy. For a long time, it was believed to be nature's only source of opioids. But it now appears that biological diversity has evolved an alternative source of opio…
Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a single source: the opium poppy. For a long time, it was believed to be nature's only source of opioids. But it now appears that biological diversity has evolved an alternative source of opio…
'Prescription Drug Diversion and Pain' provides an interdisciplinary overview of medications used to treat chronic pain, specifically the benefits and risks that are posed by long-term opioids use. This text offers a single, comprehensive source for understanding the specialzied…
Provides an interdisciplinary overview of medications used to treat chronic pain, specifically the benefits and risks that are posed by long-term opioids use. These essential pain-relieving medications must be carefully managed to prevent serious side effects that may include ph…
OPIOIDS: pharmacology, abuse, and addiction
Opioids: pharmacology, abuse, and addiction
Opioids are the mainstay in pain treatment and can be invaluable medications in palliative care. However, they are also responsible for the vast majority of preventable deaths related to drug use. This book presents an overview of the social and pharmacological aspects of opioid…
"Chronic pain places a tremendous burden on both the patient and the healthcare system. The use of opioids to address pain has resulted in negative impacts. As practitioners work to undo the current opioid crisis, options to manage pain need a new approach. Advanced Therapeutics…
Opioid abuse became one of the most serious public health concerns in the U.S. since late 1990s. Despite a variety of government interventions and pharmaceutical company efforts including prescription drug monitoring programs (PDMPs) and OxyContin reformulation, there is no sign…
The United States (U.S.) government has been attempting to combat the growing opioid epidemic ravaging the nation. The opioid epidemic has had a significant impact on public health and forensic science laboratories. Moreover, this epidemic has moderate to fatal health consequenc…
Background: Opioids with a longer duration of effect (“long-acting opioids”) are associated with risk of overdose and morbidity compared to short-acting opioids even at equivalent dosing. Guidelines recommend against initiating long-acting opioids during hospitalization. We eval…
This dissertation focuses on historic changes in public perception of narcotic use and abuse from the mid-nineteenth century to the mid-twentieth. From the 1840s to the outbreak of Civil War, politicians, physicians, the general public, and state and federal government remained …
The goal of this master’s thesis is to investigate approaches to the opioid epidemic in the Piedmont Triad Region in North Carolina. Through interviews and case study methodologies, I examine the history, functions, and resource mobilization of CURE Triad, a local organization f…
Positron emission tomography (PET) is an important and powerful nuclear imaging modality and is essential in a range of medical fields. A suitable radiotracer must be identified in order for PET imaging to provide high quality and quantifiable data about the pathology. This incl…
The US healthcare system faces numerous challenges. In this dissertation I study issues of access to care, healthcare costs, and responses to the opioid epidemic. I take an applied economic approach, using causal inference methods to examine the effects of recent policies and ch…
Iran is among the countries with the highest rates of opioid and heroin consumption in the world. Smoking opium among the Iranian population has historical and traditional roots; however the rising rate of injection drug use is a relatively new phenomenon. This project was desig…