Sulfur amino acids have critical function as intracellular redox buffers and maintain homeostasis in the external milieu by combating oxidative stress. Synthesis of glutathione (GSH) is regulated at a substrate level by cysteine, which is synthesized by homocysteine via the tran…
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Homocysteine (Hcy) has been identified as a primary risk factor for atherosclerosis as it induces endothelial cell (EC) activation/dysfunction and thus potentially initiating atherosclerotic plaque formation. There is accumulating evidence indicating a key role for oxidative str…
The entire epidermis of patients with vitiligo exhibits accumulation of up to 10-3M concentrations of hydrogen peroxide (H₂O₂) (Schallreuter, Moore et al. 1999). Over the last decade our group and others have focused on the effect of H₂O₂-mediated oxidative stress on the functio…
Inhibiting inflammatory processes or eliminating inflammation represents a logical role in the suppression and treatment strategy of cancer. Several studies have shown that anti-inflammatory drugs (NSAIDs) have promise as anticancer agents while reducing metastases and mortality…
Hair plays an important role in human social and sexual communication. The androgen-stimulated, patterned loss of hair in cases of androgenetic alopecia (or common baldness) in genetically pre-disposed individuals, is associated with ageing and can cause marked phychological dis…
In the present investigation peripheral blood lymphocytes from patients with inflammatory bowel disease (IBD) and different cancer states were treated with various agents and compared with lymphocytes from healthy control individuals (HCI) treated in the same way and measured in…
Since the discovery of cytoglobin (Cygb) a decade ago, growing amounts of data have been gathered to characterise Cygb biochemistry, functioning and implication in human pathologies. Its molecular roles remain under investigation, but nitric oxide dioxygenase and lipid peroxidas…
Aims. With the help of monitoring redox homeostasis in animal experiments, the possible beneficial effects of natural antioxidants of plant origin were investigated. Cichorium intybus (L.) extract, juice of black radish root (Raphanus sativus L. var niger ) and commercially avai…
In this study, I evaluated if dietary fatty acids, such as linoleic acid (LA) and oleic acid (OA), dietary antioxidants, such as vitamins C and E, and arachidonic acid inhibitors would modify the ability of oxidant stress to stimulate the production of the neutrophil chemokine, …
Blast injury has been coined the "signature injury of the Iraq war" resulting in a surge of interest in understanding and addressing the corresponding pathological sequelae. As modern warfare develops into a distinctly guerrilla style combat by smaller terrorist groups against l…
While diving, seals are repeatedly exposed to hypoxemia and ischemia/reperfusion. While on land, seals experience sleep apnea and prolonged periods of absolute food and water deprivation. Prolonged fasting, sleep apnea, hypoxemia and ischemia/reperfusion increase oxidant product…
Skeletal muscle contains a number of endogenous antioxidants that aid in protecting the muscle from oxidative damage. Antioxidant systems are comprised of water and lipid soluble compounds. The histidine containing dipeptides, anserine and carnosine, and α-tocopherol represent w…
Aboriginal communities in the northern Ontario region utilize an abundance of locally grown medicinal plants. However, no prior documentation or phytochemical studies on the northern Ontario medicinal plants existed in literature. This prompted me to exploit the ethnobotanical r…
Despite originally being described as a secreted protease, matrix metalloproteinase-2 (MMP-2) was recently revealed to have targets within cardiomyocytes. The biological mechanism(s) that describes the intracellular localization of MMP-2 is unknown and is thus the subject of thi…
Oxidative stress (OS) is associated with many chronic diseases including cancer, CVD and the normal process of aging. Curcumin, a dietary phytochemical has proven antioxidant, anti-inflammatory and anti-carcinogenic activity. This study aims to utilize metabolomics to evaluate a…
Amaç: Son yıllarda yapılan çalışmalar Myrtus Communis L. (MC) ekstraktının antioksidan ve antidiyabetik özelliklerini ortaya koymaktadır. Bu çalışmadaki hedefimiz bu ekstraktın yüksek yağlı diyet (YYD) ile beslenen sıçanların pankreası üzerinde etkilerini ortaya koyabilmektir. G…
Amaç: Hipertansiyon kanda ve dokularda reaktif oksijen türlerinin üretiminde artıĢa ve antioksidan kapasitenin düĢüĢüne sebep olmaktadır. Antioksidanların anjiyotensin dönüĢtürücü enzim sistemini inhibe ettiği bilinmektedir. ÇalıĢmamızda, antioksidan etkisi bilinen mersin bitkis…
Buğday (Triticum aestivum L.)’da Alüminyum Toksisitesine Karşı Kitosan Uygulamasının Etkileri Alüminyum (Al) bitki beslenmesinde gerekli olmadığı halde yer kabuğu kütlesinin % 8.1’ ini oluşturan, oksijen ve silikondan sonra en çok bulunan metalik bir elementtir. Spesifik ve biyo…
The mechanisms of arsenic’s atherogenicity, toxicity and carcinogenicity remain to be elucidated. The lung is an established target of arsenic exposure. Therefore, the present studies address the effects of arsenic on the lung and examine the role of arsenic induced oxidative st…