Introdução : A colestase neonatal, apesar de ser uma doença com baixa incidência mundial, apresenta uma elevada taxa de mortalidade se não for identificada e tratada de forma precoce. A colestase neonatal é classificada em dois grupos etiológicos distintos: colestase extra-hepát…
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O carcinoma hepatocelular constitui uma entidade rara em idade pediátrica. A presença de cirrose hepática, algumas doenças metabólicas e a colestase crónica, bem como a infeção perinatal pelo vírus da hepatite B, são fatores de risco importantes; contudo, a grande maioria dos ca…
This study analyzes a little known early twentieth century crusade to prevent tuberculosis in children with tubercular parents. To thwart the disease, indigent children presumed ‘pretubercular’ were removed from their homes and relocated to special institutions, preventoria. The…
This is the thesis component of a Doctor of Philosophy (PhD) by Published Works at the University of Salford, United Kingdom (UK). The overall submission is a portfolio of seven published works supported by five associated publications and a critical appraisal focusing on the co…
Background: Osteoporosis and vertebral fractures are common in patients with Duchenne Muscular Dystrophy (DMD) treated with glucocorticoids. Bisphosphonates (BP) have been used in pediatric patients for treatment of osteoporosis. However, the long-term effects of oral BP therapy…
Introduction: Understanding what a ‘good death’ in children might look like is important, as it impacts all stakeholders and promotes tailored support. Existing research indicates that opportunities for play, peer support and assent may be crucial. Our integrative review found m…
This thesis represents the results of three research projects that underline the breadth and depth of my interests.
Pediatric cancer survivors have been shown to have deficits in areas of cognitive function such as executive functioning following cancer treatments (i.e., radiation, chemotherapy). Research also shows that pediatric cancer survivors are at risk of experiencing poorer quality of…
The prevalence of atopic dermatitis (AD) in children has steadily increased over time, yet it remains largely unknown how maternal factors during pregnancy are associated with child AD. Few studies have specifically assessed the relationship between prenatal stress and child AD …
Primary care providers (PCPs) are often the first opportunity for individuals at risk for a genetic condition to be identified and they must care for patients with known genetic conditions. However, PCPs lag behind other providers in incorporating genetics into their practice. T…
A Síndrome da Apneia Obstrutiva do Sono (SAOS) faz parte do espetro das perturbações respiratórias obstrutivas do sono e é uma patologia de elevada prevalência na população pediátrica. Define-se como a presença de episódios recorrentes de apneias, hipopneias ou episódios mistos …