Parkinson's disease (PD) is a progressive neurodegenerative disorder, which has a devastating impact on the lives of patients, characterised primarily by the loss of dopamine-producing neurons in the brain. Drug delivery to the mammalian brain is notoriously difficult due to the…
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In recent years a great deal of research has focussed on understanding and exploiting self assembling peptides as they form fibrillar hydrogels for use in a variety of different applications, such as tissue engineering and drug delivery. A particular class of such peptide system…
The use of low-molecular weight peptide-based hydrogelators (LMWGs) for the immobilisation of enzymes is presented in this thesis. Low-molecular weight hydrogelators are a class of materials which are highly suitable for increasing enzyme lifetimes as they create a suitable biom…
Determination of protein structures (such as α-helix, β-sheet, unstructured conformation, and so on) is important to correlate the function of a protein with its structure. X-ray crystallography is a powerful technique but it requires proteins to form single crystal structure. H…
This study demonstrates a heavy isotope coding strategy for the analysis of all types of tryptic peptides, including those that are N-terminally blocked and from the C-terminus of proteins. The method exploits differential derivatization of amine and carboxyl groups generated du…