Background and aims: Endothelial dysfunction, vascular inflammation and oxidative stress have been integrally linked to the pathogenesis of both type 2 diabetes and cardiovascular disease. Aged Garlic Extract (AGE), a potent antioxidant, has been shown in previous studies to att…
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Micro/macroporous matrices comprising a continuous phase of poly([epsilon]-caprolactone) . (PCL) and a dispersed phase of water soluble particles (lactose and gelatin) with defined size range (45-90, 90-125 and l25-250[mu]m) were produced by rapid cooling solutions of PCL in ace…
Administration of lipid-mobilising factor (LMF) to mice produced a specific reduction in carcass lipid with a tendency to increase non-fat carcass mass. Treatment of murine myoblasts, myotubes and tumour cells with tumour-produced LMF, caused concentration dependent stimulation …
Endogenous glucocorticoids and serotonin have been implicated in the pathophysiology of depression, anxiety and schizophrenia. This thesis investigates the potential of downregulating expression of central Type II glucocorticoid receptors (GR) both in vitro and in vivo, with emp…
Progress made in the palliation of those with terminal cancers has allowed most symptoms to be controlled if not completely alleviated. For many in this situation now, the most overwhelming and unpleasant ongoing problems are related to the accompanying cachexia. Cachexia - (Gre…
Infection with Coxiella burnetii in humans is associated with severe disease, known as Q fever. Acute infection, that can be sub-clinical in nature, can lead to the development of a chronic life-threatening cardiac condition. The largest reported human outbreak of Q fever recent…
The role of community pharmacy (CP) in health promotion has developed over the last decade and a half following the introduction of the new National Health Service (NHS) plan in 2000. CPs have been turned into healthy living centres where individuals can access a variety of serv…
Towards the development of drug carriers that are capable of crossing the Blood Brain Barrier, the techniques of emulsion polymerisation and nanoprecipitation have been utilised to produce nanoparticulate carriers from a systematic series of alkylglyceryl dextrans (of two differ…
The spore forming bacterium, Bacillus anthracis is the aetiological agent of anthrax. The 2001 US anthrax letter attacks and the 2009‐2010 outbreak of injectional anthrax in the UK highlighted the importance of early detection and confirmation of this agent, both for patient out…
The overall aims of my PhD research project were to identify which particular gamma-amino butyric acid A receptor (GABAAR) subunits are expressed by neurochemically defined cell-types of the enteric nervous system (ENS) of the mouse colon, and what effect the pharmacological act…
Boron neutron capture therapy (BNCT) is a method for selectively destroying malignant (normally glioma) cells whilst sparing normal tissue. Irradiation of 10B (large neutron capture cross-section) with thermal neutrons effects the nuclear fission reaction: 10B + 1n → → 7Li+ + α …
Over the past forty years concerns over the presence of pharmaceuticals in the environment have grown considerably. Some pharmaceuticals can be effectively biodegraded in wastewater treatment plants but others can be sorbed onto sludges that are often subsequently used as fertil…
Duchenne muscular dystrophy (DMD) is a hereditary, X-linked, muscle wasting disease with no known cure. It is caused by altered mechanical stability of muscle cell membranes combined with altered cell signalling and inflammatory infiltrations due the absence of the cytoskeletal …
The research described in this thesis is based on novel analytical approaches to develop new methods for determining psychoactive and therapeutic drugs in biological matrices. All the analytical methods developed were according to Food and Drug Administration (FDA) guidelines. T…
This work describes the preparation of an immobilised ephedrine silica supported catalyst and its application in asymmetric synthesis. (1R,2S)-(-)-Ephedrine is a controlled substance, whose use in synthesis is closely monitored by a licence regulated by the Medicines and Healthc…
Aims The method for the confirmation of drugs of abuse for addiction testing within King’s College Hospital prior to 2008 was a labour intensive thin layer chromatography method. To replace this with a faster method more suited to future requirements, the laboratory bought a liq…
This thesis explores the notion of professionalism in pharmacy from a pharmacy education viewpoint, specifically the process of becoming a ‘professional’ as experienced by pharmacy students as they undertake the educational programme required for registration as a pharmacist. Re…
The action of bradykinin on transepithelial transfer of sodium and water in isolated rat jejunum and on smooth muscle contraction of rat terminal ileum has been investigated. (1) Bradykinin was shown to stimulate transfer at low control transfer, inhibit transfer at high control…